Anorexia nervosa is a severe psychiatric disorder associated with food avoidance and body image distortion, that is feeling fat despite being underweight. It is the third most common chronic illness among adolescent females, and its mortality reaches its peak between the ages 16 and 29 years old. There are very few treatments for anorexia nervosa and especially no biological treatments have been approved. Recent brain imaging research has repeatedly implicated brain circuits that include the insula in the disorder. The insula is a brain region important in taste processing as well as in the integration of body perception and has strong connections to the brain reward system. Transcranial magnetic stimulation (TMS) is a relatively new methodology that has been shown to alter neurocircuitry and alleviate depression. Here, the study goal is to develop TMS as a methodology to change altered neurocircuitry in anorexia nervosa and alleviate disorder specific behaviors.


Harnessing Neurostimulation to Improve Treatment Outcome in Anorexia Nervosa



Anorexia NervosaAnorexiarTMS treatment using BrainsWay Model 104 system with H1-Coil



  • University of California San Diego accepting new patients
    San DiegoCalifornia92121United States

Lead Scientist at UCSD

  • Guido Frank, MD
    Professor In Residence, Psychiatry, Vc-health Sciences-schools. Authored (or co-authored) 105 research publications. Research interests: Eating Disorders · Anorexia Nervosa · Bulimia Nervosa · Binge Eating Disorder · ARFID · Brain Imaging · Neuroscience · Treatment · Psychopharmacology · Psychotherapy


Status: accepting new patients
Start Date: 
Completion Date:  (estimated)
Sponsor: University of California, San Diego
ID: NCT05368844
Study Type: Interventional
Participants: Expecting 40 study participants
Last Updated: